High ghrelin and obestatin levels and low risk of developing fatty liver.
نویسندگان
چکیده
AIM Obesity and insulin resistance are associated with nonalcoholic fatty liver disease (NAFLD). It was recently reported that the ratio between levels of ghrelin and obestatin is also associated with obesity and insulin resistance. We investigated the association between the ghrelin/obestatin ratio and NAFLD. METHODS This cross-sectional study included 98 subjects (51 NAFLD patients and 47 controls). Anthropometric, metabolic and biochemical variables were measured and serum concentrations of ghrelin and obestatin were determined. Logistic regression analyses (univariate and multivariate) were conducted to determine whether NAFLD was associated with ghrelin and obestatin levels and the ghrelin/obestatin ratio. RESULTS We studied 51 NAFLD cases and 47 controls. Men comprised 82% of cases and 61% of controls. The mean ages of the groups differed significantly. Body mass index (P < 0.001), waist circumference (P < 0.001) and WHR (P < 0.001) were significantly greater in the NAFLD group than in the control group. The NAFLD group had higher mean fasting glucose level (P = 0.001), HOMA-IR index (P < 0.001) and triglyceride level (P < 0.001) than the controls. Ghrelin and obestatin concentrations were classed according to tertiles. Multivariate analysis revealed a negative correlation between ghrelin and obestatin levels and an overweight status, obesity and metabolic syndrome. Ghrelin and obestatin were evaluated in multivariate logistic regression analysis, they had a protective effect against hepatic steatosis after controlling for potential confounders. CONCLUSION Serum ghrelin and obestatin concentrations are correlated with a low risk of developing NAFLD. However, ghrelin/obestatin ratio was not correlated with NAFLD.
منابع مشابه
Effects of Combined Training on the Levels of Obestatin, Ghrelin, and Insulin Resistance in Overweight Women
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Introduction: Being obese and overweight lead to decreased plasma levels of such appetitive hormones as ghrelin and Obestatin. A limited number of studies have been conducted on the effects of exercise on ghrelin and obestatin, especially on humans. Therefore, this study aimed to assess the effect of 6-month Pilates exercises on plasma levels of ghrelin and Obestatin in obese old men. Methods: ...
متن کاملIs it appropriate to study blood ghrelin and obestatin in non-alcoholic fatty liver disease (NAFLD) without using protease inhibitors?
متن کامل
Plasma obestatin is lower at fasting and not suppressed by insulin in insulin-resistant humans.
Obestatin, a recently discovered 23-amino acid peptide, is involved in the regulation of appetite and body weight in antagonistic fashion to ghrelin, both deriving from a common precursor peptide. Ghrelin was shown to be associated with insulin resistance, which may also affect obestatin. We investigated the association between insulin resistance and plasma concentrations of obestatin and ghrel...
متن کاملLow prevalence of obesity in Behçet's disease is associated with high obestatin level.
OBJECTIVE Chronic inflammatory diseases are associated with altered body composition. Ghrelin has anti-inflammatory effects, and its level is altered in obesity and inflammatory diseases. The aim of the study was to evaluate the prevalence of obesity and ghrelin and obestatin levels in patients with Behçet's disease (BD). MATERIAL AND METHODS One hundred and forty-three (143) patients with BD...
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ورودعنوان ژورنال:
- Annals of hepatology
دوره 9 1 شماره
صفحات -
تاریخ انتشار 2010